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Abstract We investigate the occurrence patterns of SSEs along the shallow (15 km) portion of the Hikurangi subduction zone. First, we build a manual catalog constraining timing and length of 92 SSEs between 2006 and 2024. Then, we investigate SSE occurrence patterns by fitting a renewal process, using Bayesian inference to obtain the posterior distribution of model parameters. Our results show that SSE recurrence intervals vary along the Hikurangi margin; less frequent SSEs occur in the southern part of the margin. The periodicity of SSEs also changes along strike. SSEs in the northern part of the margin occur more regularly than those at the central part. Finally, we do not find conclusive evidence that 2016 7.8 Kaikōura earthquake had a lasting effect on SSE occurrence patterns. 

We implement a cascaded learning framework leveraging three different EDFA and fiber component models for OSNR and GSNR prediction, achieving MAEs of 0.20 and 0.14 dB over a 5-span network under dynamic channel loading. 

Optical transmission systems require accurate modeling and performance estimation for autonomous adaption and reconfiguration. We present efficient and scalable machine learning (ML) methods for modeling optical networks at component- and network-level with minimized data collection. 

Cell migration through narrow spaces is essential in wound healing and metastatic spread of cancer. Cells must deform the large nucleus to fit through constricting channels. To understand the role of the nuclear lamina in limiting cell migration through constrictions, we imaged it in cells migrating through periodic constricting channels in a microdevice. The lamina underwent cycles of wrinkling and smoothing as the nucleus changed from an irregular, rounded shape in the wide channel regions between constrictions to a smooth, hourglass shape as the nucleus passed through the center of a constriction. The laminar surface area of nuclei within constrictions was measured to be at or above the computationally predicted threshold area for the nuclear volume. The channels excluded control nuclei that had insufficient excess surface area, but not nuclei lacking lamin A/C. Thus, the excess surface area of the nuclear lamina enables cell migration through constricting channels. 

Abstract In addition to regulating the actin cytoskeleton, Cofilin also senses and responds to environmental stress. Cofilin can promote cell survival or death depending on context. Yet, many aspects of Cofilin’s role in survival need clarification. Here, we show that exposing earlyDrosophilaembryos to mild heat stress (32°C) induces a Cofilin-mediated Actin Stress Response and upregulation of heat- and ER-stress response genes. However, these responses do not alleviate the negative impacts of heat exposure. Instead, heat stressed embryos show downregulation of hundreds of developmental genes, including determinants of the embryonic body plan, and are less likely to hatch as larvae and adults. Remarkably, reducing Cofilin dosage blunts induction of all stress response pathways, mitigates downregulation of developmental genes, and completely rescues survival. Thus, Cofilin intersects with multiple stress response pathways, and modulates the transcriptomic response to heat stress. Strikingly, Cofilin knockdown emerges as a potent pro-survival manipulation for embryos.